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Her health has been undermined active. Before dying, she said Bartolomeo Domenico: «Be sure that if I die, the only reason of my death will be zeal which burns and Elongated me to the Holy Church». The split and the unsuccessful attempts to calm cruelty Urbana literally killed her, breaking the heart.
Since January 1380, she refused to even take water. By the end of the month she was in absolute shambles forces suffered convulsions, and empties into the forgotten. All the same, meeting with the forces, it is ordered to include a Mass at the Cathedral of St. Peter. By the end of February, it did not feel the legs because of paralysis. During this period, reflecting its highest psychological crisis, in the visions of her were not saints, and demons, which in its vision to stand alongside those who are caring for it. In the third Sunday of Lent in 1380, when she prayed in front of a mosaic by Giotto depicting the Church of the boat, the forces have left her and she fell. This boat before his death was to her in a vision, as if this boat (ie the church), has acquired a burden on her shoulders.
Catherine moved into her tiny cell in the streets of Pope, where it remained bedfast for about eight weeks long agony. On Sunday before the Ascension, she died in Rome at the age of 33 - equal to the age of Christ. «Present heard it repeated a long time: O God, have mercy on me, do not take away my memories of you!, Then: God, come to me for help, O Lord, help me hurry!. And finally, as if answering the prosecutor, she said: "Vanity? No, but the true glory of Christ ". She died on April 29, 1380.
Rather, her death was caused by extreme nervous and physical exhaustion (as Catherine the bulk of his life, fed very little, do not eat meat, supported forces only consecrated hosts, and if she had dinner with other people, according to the descriptions biography, so as not to offend them, share a meal, so that alone cause a vomit and get rid of food). Nevertheless, in the holy life of contemporary authors particularly point, which should be distinguished medieval anorexia mirabilis (holy anorexia) from a mental illness of modern times anorexia nervosa.